When mother of two Heather Strong disappears, suspicion falls on her estranged husband Josh Fulgham and the former babysitter-turned-lover Emilia Carr.

High School friends Pedro Bravo and Christian Aguilar are in love with the same girl. When they all go to college and she picks Christian he goes missing. Pedro pleads with the police to find his friend but may be hiding a dark secret and which his iPhone may know.

Deputy Richardson responds to a report of domestic violence along with an assault with a deadly weapon. He takes the initially non-compliant husband into custody at gun point. Deputy Campora makes a traffic stop on a vehicle with 3 women occupants, a car out of registration for 3 years, and some surprise drug habits they seemed to have acquired.

Deputy Cooney responds to a report that a man and a woman were fighting and she threatened to stab male with a knife. It becomes obvious her story bears little resemblance to reality. Deputy Fontana and Deputy Hangebrauck encounter a reported verbal disturbance outside an apartment complex. They do a search of suspects and find heroin and other goodies.

Daytona Beach, FL officers chase a suspect who fled while being served a warrant. In Toledo, OH officers are flagged down for help while in Beech Grove, IN, officers track a stolen vehicle. Berkeley County, SC officers use K9 Kai to help search for a gun.

A pregnant woman’s leg pain turns out to be flesh-eating virus, threatening life and limb. A Desert Storm war veteran swallows razor blades on a dare, and a bride-to-be spends her wedding day in the ER after collapsing at the altar.

A grown man screams incessantly for no reason, a young mother is alert but ice cold, and a young boy seems to have overdosed on drugs but denies it. All these cases are medical mysteries, requiring “outside the box”, life-saving solutions.

A college student collapses in the ER, and doctors do hours of CPR, hoping she’ll revive. A man with a 5-hour erection gets caught between his wife and his mistress, and a 70-year-old grandmother wakes up after being pronounced dead.

A young nurse collapses in the ER, and her co-workers must restart her heart. A young father brings his baby into the hospital convinced there are maggots in her hands. A witch doctor is called to the ER to exorcise a demon from a woman’s liver.

An unconscious woman is bleeding internally. Doctors must quickly assess the problem, and convince a reluctant surgeon to take the case. A man with a 4-day erection needs extraordinary help. A woman arrives in the ER with a knife in her chest.

A woman is dragged out of a house fire and has a heart attack in the ER. A schizophrenic patient believes he has someone else’s face, and an untrained medical student is mistaken for a doctor and must deliver a baby.

An ER nurse brings her delirious husband to the ER, then notices that his breath smells like mothballs. A young mother delivers her baby, then goes into life-threatening convulsions. Identical twin doctors create hilarious confusion in the ER.

A knife wielding man hangs around the lot of a convenience store. An intoxicated man in speedos flees from the police after urinating in a parking lot. An Officer responds to a domestic dispute after a man locks his girlfriend in the bathroom.

A high-speed pursuit ends in a foot chase. Stolen property is found in a suspect’s car during a traffic stop. An altercation ends with a brick being tossed at a victim’s car.

A man with a knife tries to evade police by hiding in bushes. Vice Unit Officers conduct a prostitution sting. When Officers are shot at during a pursuit, the woman claims it was flashes from a camera.

Deputies are called to a vehicle burglary in progress at an apartment complex. A traffic stop results in the discovery of drug paraphernalia. An Officer locates a stolen van and discovers drug paraphernalia in the suspect’s purse.

A college student is dropped off at the ER with her face covered in a plaster mask; doctors are baffled when a stroke patient’s heart keeps stopping and restarting without intervention; two teens arrive separately with bizarre symptoms that are similar.

An injured ER doctor puts on a show to stop a patient’s violent outbursts; a man’s heart fails as his daughter and girlfriend fight; on Christmas Eve, a burn victim’s family and doctor pray for miracles as she performs a rare treatment she’s never done.

An ER doctor gets his patient drunk to save his life and a guilty family member looks on; doctors are concerned when a patient is stiff after a fall and another is tasered by police in the ER; a boy is impaled in the neck by a bottle rocket.

A college student is dropped off at the ER with her face covered in a plaster mask; doctors are baffled when a stroke patient’s heart keeps stopping and restarting without intervention; two teens arrive separately with bizarre symptoms that are similar.

An injured ER doctor puts on a show to stop a patient’s violent outbursts; a man’s heart fails as his daughter and girlfriend fight; on Christmas Eve, a burn victim’s family and doctor pray for miracles as she performs a rare treatment she’s never done.

An ER doctor gets his patient drunk to save his life and a guilty family member looks on; doctors are concerned when a patient is stiff after a fall and another is tasered by police in the ER; a boy is impaled in the neck by a bottle rocket.